Python Full Stack Development involves using Python for both front-end and back-end development. On the front end, developers might use frameworks like Django and Flask to build dynamic web applications, while leveraging HTML, CSS, and JavaScript for user interfaces. On the back end, Python handles server-side logic, database interactions, and API integrations. Key tools include Django ORM for database management and RESTful services for scalable applications. Python’s readability and vast library ecosystem make it a popular choice for full stack development, enabling developers to build robust, scalable, and maintainable web applications from end to end.